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BT2023 MOLECULAR PATHOGENESIS SYLLABUS | ANNA UNIVERSITY BTECH BIOTECHNOLOGY 6TH SEMESTER SYLLABUS REGULATION 2008 2011 2012-2013

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BT2023 MOLECULAR PATHOGENESIS SYLLABUS | ANNA UNIVERSITY BTECH BIOTECHNOLOGY 6TH SEMESTER SYLLABUS REGULATION 2008 2011 2012-2013 BELOW IS THE ANNA UNIVERSITY SIXTH SEMESTER B.TECH BIOTECHNOLOGY DEPARTMENT SYLLABUS, TEXTBOOKS, REFERENCE BOOKS,EXAM PORTIONS,QUESTION BANK,PREVIOUS YEAR QUESTION PAPERS,MODEL QUESTION PAPERS, CLASS NOTES, IMPORTANT 2 MARKS, 8 MARKS, 16 MARKS TOPICS. IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011 2012-2013 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI, TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009

BT2023 MOLECULAR PATHOGENESIS L T P C
3 0 0 3
AIM
To develop the skills of the students in the area of Molecular Pathogenesis.
OBJECTIVES
 At the end of the course, the students would have learnt about Host Parasite
interactions, Host defense mechanisms and molecular mechanisms involved in
Pathogenesis of diseases caused by E.Coli and Vibrio. Cholerae.
UNIT I OVERVIEW 5
Historical perspective - discovery of microscope, Louis Pasteur’s contributions, Robert
Koch’s postulates, early discoveries of microbial toxins, toxic assays, vaccines,
antibiotics and birth of molecular genetics and modern molecular pathogenesis studies,
Various pathogen types and modes of entry.
UNIT II HOST-DEFENSE AGAINST PATHOGENS AND PATHOGENIC
STRATEGIES 8
Attributes & components of microbial pathogenesis, Host defense: skin, mucosa, cilia,
secretions, physical movements, limitation of free iron, antimicrobial compounds,
mechanism of killing by humoral and cellular defense mechanisms, complements,
inflammation process, general disease symptoms, Pathogenic adaptations to overcome
the above defenses.
UNIT III MOLECULAR PATHOGENESIS (WITH SPECIFIC EXAMPLES) 16
Virulence, virulence factors, virulence-associated factors and virulence lifestyle factors,
molecular genetics and gene regulation in virulence of pathogens, Vibrio Cholerae:
Cholera toxin, co-regulated pili, filamentous phage, survival E.coli pathogens:
Enterotoxigenic E.coli (ETEC), labile & stable toxins, Entero- pathogenic E.coli (EPEC),
type III secretion, cytoskeletal changes, intimate attachment; Enterohaemerrohogic
E.coli (EHEC), mechanism of bloody diarrhoea and Hemolytic Uremic Syndrome,
Enteroaggregative E.coli (EAEC). Shigella: Entry, macrophage apoptosis, induction of
macropinocytosis, uptake by epithelial cells, intracellular spread, inflammatory response,
tissue damage Plasmodium: Life cycle, erythrocyte stages, transport mechanism and
processes to support the rapidly growing schizont, parasitiparous vacuoles, and knob
protein transport, Antimalarials based on transport processes. Influenza virus:
Intracellular stages, Neuraminidase & Haemagglutinin in entry, M1 & M2 proteins in
assembly and disassembly, action of amantidine.
UNIT IV EXPERIMENTAL STUDIES ON HOST-PATHOGEN INTERACTIONS 8
Virulence assays: adherence, invasion, cytopathic, cytotoxic effects. Criteria & tests in
identifying virulence factors, attenuated mutants, molecular characterization of virulence
factors, signal transduction & host responses
UNIT V MODERN APPROACHES TO CONTROL PATHOGENS 8
Classical approaches based on serotyping. Modern diagnosis based on highly
conserved virulence factors, immuno & DNA-based techniques. New therapeutic
strategies based on recent findings on molecular pathogenesis of a variety of pathogens,
Vaccines - DNA, subunit and cocktail vaccines.
TOTAL : 45 PERIODS
59
TEXT BOOKS
1. Eduardo A. Groisman, Principles of Bacterial Pathogenesis, Academic Press, 2001.
2. Tizard : Immunology; An introduction; 4th Edition, Thomson Publication.
3. Peter Williams, Julian Ketley & George Salmond, “Methods in Microbiology: Bacterial
Pathogenesis, Vol. 27”, Academic Press, 1998.
4. Bacterial Pathogenesis – A molecular Approach, Abigali A. Salyers and Dixie D.Whitt,
Second Edition, 2002, ASM Press, Washington.
REFERENCES
1. Recent reviews in Infect. Immun., Mol. Microbiol, Biochem. J., EMBO etc.
2. Nester, Anderson, Roberts, Pearsall, Nester, “Microbiology: A Human Perspective”,
McGraw-Hill, 3rd Edition, 2001.

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