BT2353 BIOPROCESS ENGINEERING SYLLABUS | ANNA UNIVERSITY BTECH BIOTECHNOLOGY 6TH SEMESTER SYLLABUS REGULATION 2008 2011 2012-2013 BELOW IS THE ANNA UNIVERSITY SIXTH SEMESTER B.TECH BIOTECHNOLOGY DEPARTMENT SYLLABUS, TEXTBOOKS, REFERENCE BOOKS,EXAM PORTIONS,QUESTION BANK,PREVIOUS YEAR QUESTION PAPERS,MODEL QUESTION PAPERS, CLASS NOTES, IMPORTANT 2 MARKS, 8 MARKS, 16 MARKS TOPICS. IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011 2012-2013 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI, TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009
BT2353 BIOPROCESS ENGINEERING L T P C
3 0 0 3
AIM
This course aims to develop the skills of the students in the area of Bioprocess
Engineering. This will be a pre-requisite for a few elective courses and for project in
Bioprocess Technology.
OBJECTIVES
At the end of the course, the student would have learnt about stirred Tank reactors
and configuration of various reaches, and how to model and similar a Bio process.
This will help the student to undertake project in the area of Bio process Technology.
UNIT I ANALYSIS OF STR 8
Stirred tank reactor - non-ideality, RTD and stability analysis, tanks in series and
dispersion models – application to design of continuous sterilizer.
UNIT II ANALYSIS OF OTHER CONFIGURATIONS 8
Packed bed reactor, airlift reactor, fluidized bed reactor bubble column reactors – nonideality,
RTD and stability analysis.
UNIT III BIOREACTOR SCALE – UP 9
Regime analysis of bioreactor processes, oxygen mass transfer in bioreactors -
microbial oxygen demands; methods for the determination of mass transfer coefficients;
mass transfer correlations. Scale up criteria for bioreactors based on oxygen transfer,
power consumption and impeller tip speed.
UNIT IV MODELLING AND SIMULATION OF BIOPROCESSES 12
Study of structured models for analysis of various bioprocess – compartmental models,
models of cellular energetics and metabolism, single cell models, plasmid replication and
plasmid stability model. Dynamic simulation of batch, fed batch, steady and transient
culture metabolism.
UNIT V BIOREACTOR CONSIDERATION IN ENZYME SYSTEMS 8
Analysis of film and pore diffusion effects on kinetics of immobilized enzyme reactions;
formulation of dimensionless groups and calculation of effectiveness factors. Design of
immobilized enzyme reactors – packed bed, fluidized bed and membrane reactors.
TOTAL : 45 PERIODS
TEXT BOOKS
1. Anton Moser, “Bioprocess Technology”, Kinetics and Reactors”, Springer Verlag.
2. James E. Bailey & David F. Ollis, “Biochemical Engineering Fundamentals”,
McGraw-Hill.
3. Shuler and Kargl,Bioprocess Engineering, Prentice Hall , 1992.
REFERENCES
1. James M. Lee, “Biochemical Engineering”, PHI, USA.
2. EMT.EL-Mansi.CFA.Bryce, A.L.Demain, AR.Allman: Fermentation Microbiology and
Biotechnology, Second Edition 2007.
3. Harvey W. Blanch, Douglas S. Clark, “Biochemical Engineering”, Marcel Decker Inc.
BT2353 BIOPROCESS ENGINEERING L T P C
3 0 0 3
AIM
This course aims to develop the skills of the students in the area of Bioprocess
Engineering. This will be a pre-requisite for a few elective courses and for project in
Bioprocess Technology.
OBJECTIVES
At the end of the course, the student would have learnt about stirred Tank reactors
and configuration of various reaches, and how to model and similar a Bio process.
This will help the student to undertake project in the area of Bio process Technology.
UNIT I ANALYSIS OF STR 8
Stirred tank reactor - non-ideality, RTD and stability analysis, tanks in series and
dispersion models – application to design of continuous sterilizer.
UNIT II ANALYSIS OF OTHER CONFIGURATIONS 8
Packed bed reactor, airlift reactor, fluidized bed reactor bubble column reactors – nonideality,
RTD and stability analysis.
UNIT III BIOREACTOR SCALE – UP 9
Regime analysis of bioreactor processes, oxygen mass transfer in bioreactors -
microbial oxygen demands; methods for the determination of mass transfer coefficients;
mass transfer correlations. Scale up criteria for bioreactors based on oxygen transfer,
power consumption and impeller tip speed.
UNIT IV MODELLING AND SIMULATION OF BIOPROCESSES 12
Study of structured models for analysis of various bioprocess – compartmental models,
models of cellular energetics and metabolism, single cell models, plasmid replication and
plasmid stability model. Dynamic simulation of batch, fed batch, steady and transient
culture metabolism.
UNIT V BIOREACTOR CONSIDERATION IN ENZYME SYSTEMS 8
Analysis of film and pore diffusion effects on kinetics of immobilized enzyme reactions;
formulation of dimensionless groups and calculation of effectiveness factors. Design of
immobilized enzyme reactors – packed bed, fluidized bed and membrane reactors.
TOTAL : 45 PERIODS
TEXT BOOKS
1. Anton Moser, “Bioprocess Technology”, Kinetics and Reactors”, Springer Verlag.
2. James E. Bailey & David F. Ollis, “Biochemical Engineering Fundamentals”,
McGraw-Hill.
3. Shuler and Kargl,Bioprocess Engineering, Prentice Hall , 1992.
REFERENCES
1. James M. Lee, “Biochemical Engineering”, PHI, USA.
2. EMT.EL-Mansi.CFA.Bryce, A.L.Demain, AR.Allman: Fermentation Microbiology and
Biotechnology, Second Edition 2007.
3. Harvey W. Blanch, Douglas S. Clark, “Biochemical Engineering”, Marcel Decker Inc.
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