BT2351 BIOINFORMATICS – II SYLLABUS | ANNA UNIVERSITY BTECH BIOTECHNOLOGY 6TH SEMESTER SYLLABUS REGULATION 2008 2011 2012-2013 BELOW IS THE ANNA UNIVERSITY SIXTH SEMESTER B.TECH BIOTECHNOLOGY DEPARTMENT SYLLABUS, TEXTBOOKS, REFERENCE BOOKS,EXAM PORTIONS,QUESTION BANK,PREVIOUS YEAR QUESTION PAPERS,MODEL QUESTION PAPERS, CLASS NOTES, IMPORTANT 2 MARKS, 8 MARKS, 16 MARKS TOPICS. IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011 2012-2013 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI, TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009
BT2351 BIOINFORMATICS – II L T P C
3 0 0 3
UNIT I INTRODUCTION 6
Overview of Genomes of Bacteria , Archae and Eukaryota.
UNIT II PHYSICAL MAPPING TECHNIQUES 9
Top down and bottom up approach; linking and jumping of clones; genome sequencing:
placing small fragments on map: STS assembly; gap closure; pooling strategies;
cytogenetic mapping techniques
UNIT III FUNCTIONAL GENOMICS 9
Gene finding; annotation ; ORF and functional predication; Subtractive DNA library
screening; differential display and representational difference analysis; SAGE;TOGA.
UNIT IV PROTEOMICS TECHNIQUES 9
Protein level estimation; Edman protein micro sequencing; protein cleavage; 2 D gel
electrophoresis; metabolic labeling; detection of proteins on SDS gels; pattern analysis;
Mass spectrometry – principles of MALDI-TOF; tandem MS-MS; Peptide mass
fingerprinting.
47
UNIT V STRUCTURE FUNCTION RELATIONSHIP OF PROTEINS 12
Post translation modification; protein –protein interactions; glycoprotein analysis;
phosphoprotein analysis, NMR and Crystallography of protein of elucidate protein
structure, protein structure by modally.
TOTAL : 45 PERIODS
REFERENCES
1. Cantor,C.R and Smith, C.L “Geneomics”, John Wiley & Sons,1999.
2. Pennington,S.R. and Dunn, M.J.”Proteomics: from Protein Sequence to Function”,
viva books publishers, 2002.
3. Liebler, D.L. “ Introduction to Proteomics : Tools for the new Biology”, Humana press,
2002.
4. Hunt , S.P. and Livesey, F.L. “ functional genomics “, oxford university Press ,2000.
BT2351 BIOINFORMATICS – II L T P C
3 0 0 3
UNIT I INTRODUCTION 6
Overview of Genomes of Bacteria , Archae and Eukaryota.
UNIT II PHYSICAL MAPPING TECHNIQUES 9
Top down and bottom up approach; linking and jumping of clones; genome sequencing:
placing small fragments on map: STS assembly; gap closure; pooling strategies;
cytogenetic mapping techniques
UNIT III FUNCTIONAL GENOMICS 9
Gene finding; annotation ; ORF and functional predication; Subtractive DNA library
screening; differential display and representational difference analysis; SAGE;TOGA.
UNIT IV PROTEOMICS TECHNIQUES 9
Protein level estimation; Edman protein micro sequencing; protein cleavage; 2 D gel
electrophoresis; metabolic labeling; detection of proteins on SDS gels; pattern analysis;
Mass spectrometry – principles of MALDI-TOF; tandem MS-MS; Peptide mass
fingerprinting.
47
UNIT V STRUCTURE FUNCTION RELATIONSHIP OF PROTEINS 12
Post translation modification; protein –protein interactions; glycoprotein analysis;
phosphoprotein analysis, NMR and Crystallography of protein of elucidate protein
structure, protein structure by modally.
TOTAL : 45 PERIODS
REFERENCES
1. Cantor,C.R and Smith, C.L “Geneomics”, John Wiley & Sons,1999.
2. Pennington,S.R. and Dunn, M.J.”Proteomics: from Protein Sequence to Function”,
viva books publishers, 2002.
3. Liebler, D.L. “ Introduction to Proteomics : Tools for the new Biology”, Humana press,
2002.
4. Hunt , S.P. and Livesey, F.L. “ functional genomics “, oxford university Press ,2000.
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