PY3401 ADVANCED MEDICINAL CHEMISTRY SYLLABUS | ANNA UNIVERSITY B.TECH PHARMACEUTICAL 7TH SEM SYLLABUS REGULATION 2008 2011 2012-2013 BELOW IS THE ANNA UNIVERSITY SEVENTH SEMESTER B.TECH PHARMACEUTICAL DEPARTMENT SYLLABUS, TEXTBOOKS, REFERENCE BOOKS,EXAM PORTIONS,QUESTION BANK,CLASS NOTES, IMPORTANT 2 MARKS, 8 MARKS, 16 MARKS TOPICS. IT IS APPLICABLE FOR ALL STUDENTS ADMITTED IN THE YEAR 2011 2012-2013 (ANNA UNIVERSITY CHENNAI,TRICHY,MADURAI,TIRUNELVELI,COIMBATORE), 2008 REGULATION OF ANNA UNIVERSITY CHENNAI AND STUDENTS ADMITTED IN ANNA UNIVERSITY CHENNAI DURING 2009
PY3401 ADVANCED MEDICINAL CHEMISTRY
UNIT I QUANTITATIVE DESCRIPTION OF PHYSICOCHEMICAL
PROPERTIES 9
Quantitative description of physicochemical properties of drug molecules with reference
to electronic effects in drugs – Hydrophobic properties of drugs – Methods of calculating
partition coefficient – 3D structure of drugs – Other physicochemical parameters in
relation to biological action.
UNIT II QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP 9
History and development of QSAR – Classification of QSAR methodology – Hansch
analysis – Free Wilson analysis – Applications advantages and pitfalls of QSAR.
UNIT III DESIGN OF ENZYME INHIBITORS 9
Forces involved information of enzyme substrate and enzyme inhibitor complexes –
Design of rapid reversible inhibitors – Multisubstrate inhibitors – Mechanism based
inhibitors – Application with recent examples from literature.
UNIT IV DOCKING OF FLEXIBLE MOLECULES 9
Docking of flexible molecules in protein/enzyme active sites – Docking by energy
minimization superimposition – Molecular dynamic – Monte Carlo – Distance geometry
and build-up methods – Applications with recent examples from literature.
UNIT V COMPUTER-AIDED DEVELOPMENT OF THREE-DIMENSIONAL
PHARMACOPHORE MODES 9
Direct and indirect ligand design – The pharmacophore concept – Steps in 3-Dpharamacophore
identification – Selection of pharmacophore elements – Representation
of pharmacophore elements as ligand points or site points – Receptor exclude and
receptor essential volumes.
L: 45 T: 15 TOTAL: 60 PERIODS
TEXT BOOKS
1. Kadam, S.S., Mahadik, K.R. and Bothara, K.G., “Principles of Medicinal
Chemistry”, Vol. I and Vol. II, 7th Edition, Nirali Prakashan Publications, 1999.
2. Remers, W.A. and Delgado, J.N., “Wilson and Gisvold’s Textbook of
Pharmaceutical Organic Chemistry”, Lippincott William and Wilkins, 2004.
REFERENCES
1. Wolff, M.E., “Burger’s Medicinal Chemistry”, 5th Edition, Vol. I – V, John Willey
and Sons, 2003.
2. Hansch, C., “Comprehensive Medicinal Chemistry”, Vol.4, Pergamon Press,
1998.
3. Leach A.R., “Molecular Modeling and Drug Design” 2nd Edition, Pearson
Prentice-Hall, 2001.
PY3401 ADVANCED MEDICINAL CHEMISTRY
UNIT I QUANTITATIVE DESCRIPTION OF PHYSICOCHEMICAL
PROPERTIES 9
Quantitative description of physicochemical properties of drug molecules with reference
to electronic effects in drugs – Hydrophobic properties of drugs – Methods of calculating
partition coefficient – 3D structure of drugs – Other physicochemical parameters in
relation to biological action.
UNIT II QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP 9
History and development of QSAR – Classification of QSAR methodology – Hansch
analysis – Free Wilson analysis – Applications advantages and pitfalls of QSAR.
UNIT III DESIGN OF ENZYME INHIBITORS 9
Forces involved information of enzyme substrate and enzyme inhibitor complexes –
Design of rapid reversible inhibitors – Multisubstrate inhibitors – Mechanism based
inhibitors – Application with recent examples from literature.
UNIT IV DOCKING OF FLEXIBLE MOLECULES 9
Docking of flexible molecules in protein/enzyme active sites – Docking by energy
minimization superimposition – Molecular dynamic – Monte Carlo – Distance geometry
and build-up methods – Applications with recent examples from literature.
UNIT V COMPUTER-AIDED DEVELOPMENT OF THREE-DIMENSIONAL
PHARMACOPHORE MODES 9
Direct and indirect ligand design – The pharmacophore concept – Steps in 3-Dpharamacophore
identification – Selection of pharmacophore elements – Representation
of pharmacophore elements as ligand points or site points – Receptor exclude and
receptor essential volumes.
L: 45 T: 15 TOTAL: 60 PERIODS
TEXT BOOKS
1. Kadam, S.S., Mahadik, K.R. and Bothara, K.G., “Principles of Medicinal
Chemistry”, Vol. I and Vol. II, 7th Edition, Nirali Prakashan Publications, 1999.
2. Remers, W.A. and Delgado, J.N., “Wilson and Gisvold’s Textbook of
Pharmaceutical Organic Chemistry”, Lippincott William and Wilkins, 2004.
REFERENCES
1. Wolff, M.E., “Burger’s Medicinal Chemistry”, 5th Edition, Vol. I – V, John Willey
and Sons, 2003.
2. Hansch, C., “Comprehensive Medicinal Chemistry”, Vol.4, Pergamon Press,
1998.
3. Leach A.R., “Molecular Modeling and Drug Design” 2nd Edition, Pearson
Prentice-Hall, 2001.
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